The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes

@article{Zhang2018ThePT,
  title={The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes},
  author={Donglei Zhang and Shikui Tu and Michael Stubna and Wei-Sheng Wu and Wei-Che Huang and Zhiping Weng and Heng-Chi Lee},
  journal={Science},
  year={2018},
  volume={359},
  pages={587-592}
}
Piwi-interacting RNAs (piRNAs) silence transposons to safeguard genome integrity in animals. However, the functions of the many piRNAs that do not map to transposons remain unknown. Here, we show that piRNA targeting in Caenorhabditis elegans can tolerate a few mismatches but prefer perfect pairing at the seed region. The broad targeting capacity of piRNAs… CONTINUE READING