The phytotoxin albicidin is a novel inhibitor of DNA gyrase.

  title={The phytotoxin albicidin is a novel inhibitor of DNA gyrase.},
  author={Saeed M. Hashimi and Melisa K. Wall and Andrew W. B. Smith and Anthony Maxwell and Robert G. Birch},
  journal={Antimicrobial agents and chemotherapy},
  volume={51 1},
Xanthomonas albilineans produces a family of polyketide-peptide compounds called albicidins which are highly potent antibiotics and phytotoxins as a result of their inhibition of prokaryotic DNA replication. Here we show that albicidin is a potent inhibitor of the supercoiling activity of bacterial and plant DNA gyrases, with 50% inhibitory concentrations (40 to 50 nM) less than those of most coumarins and quinolones. Albicidin blocks the religation of the cleaved DNA intermediate during the… CONTINUE READING
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