The phytoestrogens daidzein and genistein enhance the insulin-stimulated sulfate uptake in articular chondrocytes

@article{Claassen2008ThePD,
  title={The phytoestrogens daidzein and genistein enhance the insulin-stimulated sulfate uptake in articular chondrocytes},
  author={H. Claassen and V. Briese and F. Manapov and B. Nebe and M. Sch{\"u}nke and B. Kurz},
  journal={Cell and Tissue Research},
  year={2008},
  volume={333},
  pages={71-79}
}
Clinical observations have suggested a relationship between osteoarthritis and a changed estrogen metabolism in menopausal women. Phytoestrogens have been shown to ameliorate various menopausal symptoms. Proteoglycans (PG) consisting of low and high sulfated glycosaminoglycans (GAG) are the main components of articular cartilage matrix, and their synthesis is increased by insulin in growth plate cartilage. We have investigated whether GAG synthesis and sodium [35S]sulfate incorporation in… Expand
Phytoestrogen (Daidzein) Promotes Chondrogenic Phenotype of Human Chondrocytes in 2D and 3D Culture Systems
Biological Effects of the Herbal Plant-Derived Phytoestrogen Bavachin in Primary Rat Chondrocytes.
Genistein treatment increases bone mass in obese, hyperglycemic mice
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