The physiology of growth hormones (GHs) in pregnant women and partial characterization of the placental GH variant.

@article{Frankenne1988ThePO,
  title={The physiology of growth hormones (GHs) in pregnant women and partial characterization of the placental GH variant.},
  author={Françis Frankenne and Jean L Closset and Fulgencio Gomez and M L Scippo and Jean Smal and Georges P Hennen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1988},
  volume={66 6},
  pages={1171-80}
}
This work was undertaken to study the heterogeneity of GH in serum and placental and pituitary extracts and to study GH physiology in pregnant women. Two distinct monoclonal antihuman GH (anti-hGH) antibodies (MAb) coded 5B4 and K24 were selected for their high binding affinity and specificity. The 5B4 MAb recognized the epitope comprising the NH2-terminal end of hGH, and the K24 MAb recognized an internal epitope. Both MAbs were used in RIAs to measure serum GH concentrations in various… CONTINUE READING

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