The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction

@article{Welt2002ThePA,
  title={The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction},
  author={Corrine K Welt},
  journal={Current Opinion in Obstetrics and Gynecology},
  year={2002},
  volume={14},
  pages={317-323}
}
  • C. Welt
  • Published 1 June 2002
  • Biology, Medicine
  • Current Opinion in Obstetrics and Gynecology
In the last 2 years, major advances have been made in the understanding of inhibin physiology. Discovery of an inhibin receptor and binding protein has expanded our knowledge of the mechanism whereby inhibin antagonizes activin action. Controlled experimental studies have clarified the regulation and physiology of inhibin A and inhibin B, providing evidence for their use as markers of ovarian function. Clinical studies continue to uphold the use of inhibin as a marker for ovarian cancer, but… 

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  • D. Robertson
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  • 2012

Significance of inhibin in reproductive pathophysiology and current clinical applications.

Activins, Inhibins, and Follistatins in Reproduction

  • J. Buster
  • Biology
    The Journal of the Society for Gynecologic Investigation: JSGI
  • 2003

Normal Reproductive Function in InhBP/p120-Deficient Mice

The InhBP/p120 mutant male and female mice were viable and fertile and showed no alterations in FSH synthesis or secretion or in ovarian or testicular function, contributing to a growing body of evidence indicating that Inh BP/ p120 does not play an essential role in inhibin biology.

Clinical and Therapeutic Implications of Follistatin in Solid Tumours.

Follistatin plays a role in tumourigenesis, metastasis and angiogenesis of solid tumours through its interaction with activin and BMPs, thus resulting in pathophysiological function.

Inhibin-βA subunit immunolabeling as a prognostic factor in endometrioid adenocarcinomas: a matter of evaluation?

  • I. Mylonas
  • Medicine, Biology
    Archives of Gynecology and Obstetrics
  • 2010
Evaluation of staining intensity revealed better cause-specific survival in patients with negative or low inhibin-βA immunolabeling intensity, although of some use, semi-quantification of immunohistochemical reactions might not be definitive for evaluation of the inhibitedin- βA subunit as a prognostic marker in endometrial cancer patients.

Emerging role of inhibin as a biomarker for ovarian cancer.

A test for serum inhibin has been developed which is able to diagnose granulosa cell tumors and mucinous carcinomas with high accuracy and when used in conjunction with the CA125 test, the two tests detect the majority of ovarian cancers with high sensitivity and specificity.

Emerging Role of Inhibin as a Biomarker for Ovarian Cancer

A test for serum inhibin has been developed which is able to diagnose granulosa cell tumors and mucinous carcinomas with high accuracy and when used in conjunction with the CA125 test, the two tests detect the majority of ovarian cancers with high sensitivity and specificity.

Inhibin/activin-betaC and -betaE subunits in the Ishikawa human endometrial adenocarcinoma cell line

It is shown for the first time that the novel inhibin/activin-betaC and -betaE subunits are expressed in normal human endometrium and the estrogen receptor positive human endometricrial carcinoma cell line Ishikawa using RT-PCR and immunohistochemical detection methods.

Inhibin-α subunit expression in uterine endometrioid adenocarcinomas and endometrial cancer cell lines: a potential prognostic factor.

  • I. Mylonas
  • Biology, Medicine
    International journal of molecular medicine
  • 2011
Inhibin-α seems to have a substantial role in the carcinogenesis and pathology of uterine endometrioid carcinomas, and might be used as a marker to identify high-risk patients and may aid in the selection of patients for a more aggressive adjuvant therapy.
...

References

SHOWING 1-10 OF 81 REFERENCES

Antagonism of activin by inhibin and inhibin receptors: a functional role for betaglycan.

Recent advances in understanding inhibin's mode of action are summarized focusing on the recent identification of betaglycan as an inhibin co-receptor capable of mediating inhibin action.

An update on the roles of inhibin, activin, and follistatin as local regulators of folliculogenesis.

  • J. Findlay
  • Biology, Medicine
    Biology of reproduction
  • 1993
It is concluded that inhibin has a paracrine action positively regulating LH-induced androgen production by theca cells in addition to a peripheral role regulating FSH secretion.

Activin Stimulates Proliferation of Rat Ovarian Thecal-Interstitial Cells1

An activin-follistatin system may be involved in the regulation of the size of ovarian thecal-stromal compartment, and stimulation of T-I proliferation by these agents is likely to be mediated via separate transduction pathways.

Dynamic changes in the intrafollicular inhibin/activin/follistatin axis during human follicular development: relationship to circulating hormone concentrations.

The pattern of intrafollicular hormone biosynthesis across antral follicle development in normal women was determined and the hypothesis that the orderly transition from an activin-Dominant to an inhibin A/FS-dominant microenvironment is critical for dominant follicles development was consistent.

Dynamics of inhibin subunit and follistatin mRNA during development of normal and polycystic ovary syndrome follicles.

The results suggest that insufficient production of inhibin alpha and possibly beta(A)-subunits, but not follistatin, is associated with follicular arrest in polycystic ovary syndrome follicles.

Inhibin A and inhibin B responses to gonadotropin withdrawal depends on stage of follicle development.

Administration of a GnRH antagonist at precise stages of the menstrual cycle provides further evidence that differential regulation of inhibin A and inhibin B is critically dependent on the stage of follicular development.

Inhibin A and inhibin B in women with polycystic ovarian syndrome during treatment with FSH to induce mono‐ovulation

The concentration of FSH and LH and the ovarian hormones oestradiol, inhibin A and B, in relation to the dynamics of follicular development in women with PCOS under basal conditions and during treatment with FSH are measured.

Serum α-Inhibin Levels in Polycystic Ovary Syndrome: Relationship to the Serum Androstenedione Level1

Serum α-inhibin levels together with LH and androstenedione (A) levels were significantly increased in PCOS women, and simple and partial regression analysis demonstrated that serum A levels were positively and independently correlated to serum α-Inhibin.
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