The physiological role of pyruvate carboxylation in hamster brown adipose tissue.

  title={The physiological role of pyruvate carboxylation in hamster brown adipose tissue.},
  author={Barbara A Cannon and Jan Nedergaard},
  journal={European journal of biochemistry},
  volume={94 2},
1. Pyruvate carboxylase is present in brown adipose tissue mitochondria. 2. In isolated mitochondria, pyruvate, bicarbonate and ATP, the substrates for pyruvate carboxylase, are able to replace added malate in supplying a condensing partner for acetyl-CoA formed from beta-oxidation of fatty acids. 3. In brown adipocytes, pyruvate and CO2 increase the rate of norepinephrine-stimulated respiration synergistically. 4. The norepinephrine-stimulated respiration in brown adipocytes is diminished when… CONTINUE READING


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