The physiological role of IGFBP-1.

  title={The physiological role of IGFBP-1.},
  author={Jeff M. P. Holly},
  journal={Acta endocrinologica},
  volume={124 Suppl 2},
It appears that a readily available pool of IGF is achieved by IGFBPs, primarily IGFBP-3, that maintain a relatively constant high level of IGF. A circulating enzyme is present in the circulation which can modify IGFBP-3. When IGF levels are low this enzyme may be activated to alter the availability of the limited reserves of IGF to the tissues. In conditions where fuel supplies are compromised IGF-actions can be modulated by acute changes in IGFBP-1 levels. The extent to which IGFBP-1 acts by… CONTINUE READING

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