The physiological effect of ingested β-N-methylamino-L-alanine on a glutamatergic synapse in an in vivo preparation.

@article{Goto2012ThePE,
  title={The physiological effect of ingested β-N-methylamino-L-alanine on a glutamatergic synapse in an in vivo preparation.},
  author={Joy J. Goto and Jane H Koenig and Kazuo Ikeda},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  year={2012},
  volume={156 3-4},
  pages={
          171-7
        }
}
The neurotoxin, BMAA (β-N-methylamino-L-alanine), may be a risk factor for amyotrophic lateral sclerosis (ALS), Parkinson's (PD) and Alzheimer's (AD) disease. In vivo experiments have demonstrated that BMAA can cause a number of motor dysfunctions if ingested or injected, and in vitro experiments show that this toxin binds to glutamate receptors with deleterious results. Also, BMAA exists in the human food chain worldwide, and has been detected in the brains of ALS and AD patients. This paper… CONTINUE READING

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VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 43 REFERENCES

A novel lenticular walking arena to quantify locomotory competence in fruit flies

N. Mekdara, J. Goto, +5 authors U. Muller
  • J. Exp. Zool. A.: Ecol. Genet
  • 2012
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

L-beta-methylamino-alanine-induced behavioral changes in rats.

  • Pharmacology, biochemistry, and behavior
  • 1993
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL