The physiological and clinical effects of progesterone inhibition with mifepristone (RU 486) in the second trimester.

@article{Hill1990ThePA,
  title={The physiological and clinical effects of progesterone inhibition with mifepristone (RU 486) in the second trimester.},
  author={Ned C. Hill and Mark Selinger and James Ferguson and Andr{\'e}s L{\'o}pez Bernal and Ian Z Mackenzie},
  journal={British journal of obstetrics and gynaecology},
  year={1990},
  volume={97 6},
  pages={487-92}
}
A double-blind placebo-controlled trial was performed in 20 primigravidae to assess the physiological and clinical effects of oral mifepristone on myometrial contractility and sensitivity in the second trimester. Ten women received 600 mg of oral mifepristone and 10 women a placebo 24 h before abortion was induced in both groups, with extra-amniotic PGE2 instillation. Intrauterine pressure recordings demonstrated increased spontaneous uterine activity and increased sensitivity to PGE2 and… CONTINUE READING