The physiological action of β‐iminazolylethylamine

@article{DaleThePA,
  title={The physiological action of $\beta$‐iminazolylethylamine},
  author={Henry Hallett Dale and Patrick Playfair Laidlaw},
  journal={The Journal of Physiology},
  volume={41}
}
,8-IMINAZOLYLETHYLAMINE is the amine which is produced when carbon dioxide is split off from histidine. It was first prepared synthetically by Windaus and Vogt'. Recently Ackermann2 obtained a large yield of the base by submitting histidine to the action of putrefactive organisms. It has been shown that several of the amines thus related to amino-acids possess marked physiological activity. The activity of j8-iminazolylethylamine was discovered in the course of the investigation of ergot and… 
Developments in antihistamines (H1).
  • A. Saxena, M. Saxena
  • Biology
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques
  • 1992
TLDR
It has been shown that cell bodies immunoreactive to histamine and histidine decarboxylase are restricted to the ventral part of the posterior hypothalamus and mammillary nuclei regions but send projections to almost all regions of the diencephalon and telencephalon.
BETA DIMETHYLAMINOETHYL BENZHYDRYL ETHER HYDROCHLORIDE (BENADRYL) IN TREATMENT OF URTICARIA
Considerable evidence has been presented by Lewis 1 to support the conclusion that a diffusible substance is responsible for the development of the urticarial lesion which comprises "the triple
Histamine, Histamine Antagonists and Cromones
TLDR
There was an extensive study of its biological effects by DALE and LAIDLAW (1910,1911), who noted the parallel between the actions of histamine in animals and the response of an animal to a foreign protein, normally inert, but to which the animal had been sensitised by prior injection.
REDUKTIONEN UND OXYDATIONEN BET BIOLOGISCHEN STRAHLENWIRKUNGEN
TLDR
Three main sections deal with the accelerating effect of ultraviolet rays on the process of reduction within the skin which occurs at the sulfhydryl groups of the germinal layer after exposure to light.
Synthesis of Imidazol-2-yl Amino Acids by Using Cells from Alkane-Oxidizing Bacteria
TLDR
The product pattern as well as the transformation pathway of N-(2-hexylamino-4-phenylimidazol-1-yl)-acetamide differed in the various strains used, and the acetylamino group of these products and of the substrate was transformed to an amino group.
Preliminary evidence for two subclasses of histamine H2-receptors
TLDR
It was found that there were several actions of histamine which were not antagonized by the antihistaminic agents then available, which included inhibition of the rat uterus, stimulation of the heart and stimulation of gastric acid secretion.
THE PHARMACOLOGY OF HISTAMINE: WITH A BRIEF SURVEY OF EVIDENCE FOR ITS OCCURRENCE, LIBERATION, AND PARTICIPATION IN NATURAL REACTIONS
It was in August, 1907, while watching a demonstration a t an International Physiological Congress at Heidelberg, that I first became conscious of the existence, in certain extracts of ergot, of a
The metabolism and functions of histamine.
TLDR
Two decades of research were required to establish the importance of intracellular histamine and the physiological significance of its release and the classical observations of Thomas Lewis on the whealing response in human skin were of note.
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