The physiologic basis of diuretic synergism: its role in treating diuretic resistance.

@article{Ellison1991ThePB,
  title={The physiologic basis of diuretic synergism: its role in treating diuretic resistance.},
  author={David H Ellison},
  journal={Annals of internal medicine},
  year={1991},
  volume={114 10},
  pages={886-94}
}
Diuretic drugs usually improve edema when used judiciously. Some patients, however, become resistant to their effects. Diuretic resistance may result from dietary indiscretion, poor compliance, impaired bioavailability, imparied diuretic secretion into the lumen of the renal tubule, or because other drugs interfere with diuretic activity. When easily treatable causes of diuretic resistance have been excluded, resistance often reflects the intensity of the stimuli to sodium retention. Recent… CONTINUE READING