The physicochemical characteristics of freeze-dried scutellarin-cyclodextrin tetracomponent complexes.

@article{Cao2005ThePC,
  title={The physicochemical characteristics of freeze-dried scutellarin-cyclodextrin tetracomponent complexes.},
  author={Feng Cao and Jianxin Guo and Qineng Neng Ping},
  journal={Drug development and industrial pharmacy},
  year={2005},
  volume={31 8},
  pages={747-56}
}
In an effort to improve the solubility of the insoluble drug scutellarin, a novel complexation of scutellarin with beta-cyclodextrin (beta-CD) was studied. Tetracomponent freeze-dried complex was prepared with scutellarin, beta-CD, Hydroxypropyl Methylcellulose (HPMC), and triethanolamine. To confirm complex formation, complex was characterized by Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction, and differential scanning calorimetry (DSC). Phase-solubility analysis… CONTINUE READING