The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man.

@article{Carey1978ThePC,
  title={The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man.},
  author={Martin C. Carey and Donald M. Small},
  journal={The Journal of clinical investigation},
  year={1978},
  volume={61 4},
  pages={998-1026}
}
We determined the maximum solubilities of cholesterol in aqueous conjugated bile salt-egg lecithin-cholesterol systems as a function of several physical-chemical variables including those of physiological importance employing phase equilibria techniques. Equilibration rates are influenced by time and the method of sample preparation in that metastable supersaturation is readily induced at high bile salt: lecithin ratios, and equilibrium saturation by dissolution is achieved sluggisly at low… CONTINUE READING
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