The physical basis of renal fibrosis: effects of altered hydrodynamic forces on kidney homeostasis.

@article{Grabias2014ThePB,
  title={The physical basis of renal fibrosis: effects of altered hydrodynamic forces on kidney homeostasis.},
  author={Bryan M Grabias and Konstantinos Konstantopoulos},
  journal={American journal of physiology. Renal physiology},
  year={2014},
  volume={306 5},
  pages={F473-85}
}
Healthy kidneys are continuously exposed to an array of physical forces as they filter the blood: shear stress along the inner lumen of the tubules, distension of the tubular walls in response to changing fluid pressures, and bending moments along both the cilia and microvilli of individual epithelial cells that comprise the tubules. Dysregulation of kidney homeostasis via underlying medical conditions such as hypertension, diabetes, or glomerulonephritis fundamentally elevates the magnitudes… CONTINUE READING