The phylogeny of the complement system and the origins of the classical pathway.

@article{Dodds2007ThePO,
  title={The phylogeny of the complement system and the origins of the classical pathway.},
  author={Alister W. Dodds and Misao Matsushita},
  journal={Immunobiology},
  year={2007},
  volume={212 4-5},
  pages={
          233-43
        }
}
The origins of the complement system have now been traced to near to the beginnings of multi-cellular animal life. Most of the evidence points to the earliest activation mechanism having been more similar to the lectin pathway than to the alternative pathway. C1q, the immunoglobulin recognition molecule of the classical pathway of the vertebrates, has now been shown to predate the development of antibody as it has been found in the lamprey, a jawless fish that lacks an acquired immune system… CONTINUE READING

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