The photochemical reaction cycle of proteorhodopsin at low pH.

@article{Lakatos2003ThePR,
  title={The photochemical reaction cycle of proteorhodopsin at low pH.},
  author={Melinda Lakatos and Janos K. Lanyi and J{\'u}li{\'a}nna Szak{\'a}cs and G. Varo},
  journal={Biophysical journal},
  year={2003},
  volume={84 5},
  pages={3252-6}
}
The proton acceptor group in the recently described retinal protein, proteorhodopsin has an unusually high pK(a) of 7.1. It was shown that at pH above this pK(a), illumination initiates a photocycle similar to that of bacteriorhodopsin, and the protein transports proton across the cell membrane. Recently it was reported that proteorhodopsin, unlike bacteriorhodopsin, transports protons at pH below the pK(a) of the proton acceptor, and this transport is in the reverse direction. We have… CONTINUE READING