The photochemical mechanism of a B12-dependent photoreceptor protein

  title={The photochemical mechanism of a B12-dependent photoreceptor protein},
  author={Roger J Kutta and Samantha J O Hardman and Linus O. Johannissen and Bruno Bellina and Hanan L. Messiha and Juan Manuel Ortiz-Guerrero and Montserrat El{\'i}as-Arnanz and Sachin Padmanabhan and Perdita E Barran and Nigel S. Scrutton and Alex J. Jones},
  booktitle={Nature communications},
The coenzyme B12-dependent photoreceptor protein, CarH, is a bacterial transcriptional regulator that controls the biosynthesis of carotenoids in response to light. On binding of coenzyme B12 the monomeric apoprotein forms tetramers in the dark, which bind operator DNA thus blocking transcription. Under illumination the CarH tetramer dissociates, weakening its affinity for DNA and allowing transcription. The mechanism by which this occurs is unknown. Here we describe the photochemistry in CarH… CONTINUE READING
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