The photochemical binding of bithionol to soluble proteins and peptides.

  title={The photochemical binding of bithionol to soluble proteins and peptides.},
  author={Jonathan N. Delahanty and J. Catherine Evans and Christopher C. Rowlands and Ruth U Pendlington and M. D. Barratt},
  journal={Biochemical pharmacology},
  volume={38 21},

Photochemical binding of photoallergens to human serum albumin: A simple in vitro method for screening potential photoallergens.

Phosphorylation of histone H2AX is a powerful tool for detecting chemical photogenotoxicity.

It is clarified that phosphorylated histone H2AX (γ-H2AX), which was produced with the induction of DNA double-strand breaks, is a sensitive photogenotoxic marker.

Evaluation of chemical phototoxicity, focusing on phosphorylated histone H2AX

It is found that the γ-H2AX assay exhibited high sensitivity and a low false-positive rate as a detection system of genotoxic potential as well as the toxic impact of various environmental stresses such as chemicals, light and/or their coexposure using γ, H2AX.

False-negative chemicals in ESR-based photosafety test (ESR-PT) and their significance for photosafety evaluations: examples of bithionol, fenticlor and cilnidipine.

The electron spin resonance (ESR)-based photosafety test (ESR-PT) is a non-animal prediction test for photosafety evaluations that can be used even for hydrophobic chemicals; the method is based on



Photochemical reactions of fentichlor with soluble proteins.

The use of maleic anhydride for the reversible blocking of amino groups in polypeptide chains.

The unblocking reaction can be used as the basis for a ;diagonal'-electrophoretic separation of lysine peptides and N-terminal peptides, as shown by studies with beta-melanocyte-stimulating hormone.


Evidence is shown for the existence of a major strong binding site for the photochemical binding of T4CS to HSA.

Induction of photoallergy in guinea-pigs by injection of photoallergen-protein conjugates.

The results demonstrate the importance of protein conjugate formation in the induction of photoallergy, i.e. the role of carrier protein in contact sensitivity, and suggests that albumin may have a special role as a carrierprotein in T4CS photo allergy.

Photoreactions of 3,3',4',5-tetrachlorosalicylanilide with proteins.

The results presented indicate that not all proteins in the skin are capable of being the carrier protein in photoallergy of TCSA- and that cross reactivity to other halogenated salicylanilides can be explained by further photochemical reactions ofTCSA- photoproducts.

Primary structure of peptides released during activation of human plasminogen by urokinase.

  • B. Wiman
  • Biology, Chemistry
    European journal of biochemistry
  • 1973
From results it is shown that API and APII, in intact plasminogen, occupy the positions 1–63 and 64–68 respectively, and the residue in position 69 is shown to be methionine, which also is the NH2-terminal amino acid found in the intermediate compound formed during activation.

Photoallergies to fenticlor and Multifungin.

  • J. Burry
  • Medicine
    Archives of dermatology
  • 1967
Both localized and generalized photoallergies were noted in the same patient and the generalized sensitivity was transient, with emphasis placed upon the role that the abundant Australian sunshine must play.