• DOI:10.1016/0006-2952(89)90599-6
Corpus ID: 19688173

The photochemical binding of bithionol to soluble proteins and peptides.

@article{Delahanty1989ThePB,
  title={The photochemical binding of bithionol to soluble proteins and peptides.},
  author={J. N. Delahanty and J. Evans and C. Rowlands and R. Pendlington and M. Barratt},
  journal={Biochemical pharmacology},
  year={1989},
  volume={38 21},
  pages={
          3879-83
        }
}

• J. N. Delahanty, J. Evans, +2 authors M. Barratt
• Published 1989
• Chemistry, Medicine
• Biochemical pharmacology

The photochemical reactions of the bacteriocide bithionol (a known photoallergen in man) with soluble proteins and peptides, were investigated. Solutions of human serum albumin (HSA), human gamma-globulin, bovine insulin and poly-L-lysine were irradiated with ultraviolet light of wavelength 313 nm in the presence of [35S]-bithionol and the extent of photochemical (covalent) binding determined. HSA bound at least four molecules of bithionol per molecule of HSA. Bithionol was also found to bind… Expand