The photobiogenesis and metabolism of vitamin D.

  title={The photobiogenesis and metabolism of vitamin D.},
  author={Michael F Holick and Mary Beth Clark},
  journal={Federation proceedings},
  volume={37 12},
Provitamin D3 (7-dehydrocholesterol) is converted to previtamin D3 by the action of ultraviolet radiation on the skin. Previtamin D3 thermally isomerizes to vitamin D3 in the skin and the vitamin is then transported to the liver on the vitamin D-binding protein. Although there are extrahepatic vitamin D-25-hydroxylases, the liver is the major site for the 25-hydroxylation of vitamin D. In response to hypocalcemia and hypophosphatemia, 25-OH-D is metabolized by a renal-cytochrome. P450-dependent… CONTINUE READING


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