The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.

@article{Hanke2009ThePI,
  title={The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.},
  author={Stefan Hanke and Matthias Mann},
  journal={Molecular & cellular proteomics : MCP},
  year={2009},
  volume={8 3},
  pages={519-34}
}
The insulin signaling pathway is critical in regulating glucose levels and is associated with diabetes, obesity, and longevity. A tyrosine phosphorylation cascade creates docking sites for protein interactions, initiating subsequent propagation of the signal throughout the cell. The phosphotyrosine interactome of this medically important pathway has not yet been studied comprehensively. We therefore applied quantitative interaction proteomics to exhaustively profile all potential… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

LC-MS/MS in Proteomics

Methods in Molecular Biology • 2010
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 103 references

Defining the specificity space of the human SRC homology 2 domain.

Molecular & cellular proteomics : MCP • 2008
View 4 Excerpts
Highly Influenced

C 2 can do it , too

H. R. Christofk, M. G. Vander Heiden, N. Wu, J. M. Asara, L. C. Cantley
2008

Can proteomics retire the western blot?

Journal of proteome research • 2008

Dissection of the insulin signaling pathway via quantitative phosphoproteomics

M. Kruger, I. Kratchmarova, +3 authors M. Mann
Proc. Natl. Acad. Sci. U. S. A • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…