The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo.

@article{Atochin2007ThePS,
  title={The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo.},
  author={Dmitriy N. Atochin and Annie Z Wang and Victor W. Liu and Jeffrey D Critchlow and Ana Paula Villela Dantas and Robin C Looft-Wilson and Takahisa Murata and Salvatore Salomone and Hwa Kyoung Shin and Cenk Ayata and Michael A. Moskowitz and Thomas Michel and William C Sessa and Paul Lee Huang},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 7},
  pages={1961-7}
}
NO plays critical roles in vascular function. We show that modulation of the eNOS serine 1179 (S1179) phosphorylation site affects vascular reactivity and determines stroke size in vivo. Transgenic mice expressing only a phosphomimetic (S1179D) form of eNOS show greater vascular reactivity, develop less severe strokes, and have improved cerebral blood flow in a middle cerebral artery occlusion model than mice expressing an unphosphorylatable (S1179A) form. These results provide a molecular… CONTINUE READING
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