The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.

@article{Hashimoto2006ThePC,
  title={The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.},
  author={Yoshitami Hashimoto and Tsuyoshi Tsujimura and Akio Sugino and Haruhiko Takisawa},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2006},
  volume={11 9},
  pages={
          993-1007
        }
}
ATR-dependent activation of the kinase Chk1 is the initial step in signal transduction in the DNA replication checkpoint, which allows a cell to enter mitosis only after the completion of DNA replication. TopBP1-related proteins in higher eukaryotes are implicated in the replication checkpoint, but their exact role remains elusive because of their requirements for replication initiation. Here we report that the initiation function of Xenopus Cut5/TopBP1 could be entirely separated from its… CONTINUE READING

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