The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis.

@article{Harnett2008ThePM,
  title={The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis.},
  author={Margaret M Harnett and Dorothy E. Kean and Agn{\`e}s Boitelle and Shay McGuiness and T. Thalhamer and Christina N. Steiger and Catherine A. Egan and Lamyaa Al-Riyami and Marcos Julio Caruso Alcocer and Katrina M. Houston and J. Alastair Gracie and Iain B. Mcinnes and W Harnett},
  journal={Annals of the rheumatic diseases},
  year={2008},
  volume={67 4},
  pages={518-23}
}
OBJECTIVE In countries where parasitic infections are endemic, autoimmune disease is relatively rare, leading to the hypothesis that parasite-derived immunomodulators may protect against its development. Consistent with this, we have previously demonstrated that ES-62, a 62 kDa phosphorylcholine (PC)-containing glycoprotein that is secreted by filarial nematodes, can exert anti-inflammatory action in the murine collagen-induced arthritis (CIA) model and human rheumatoid arthritis-derived… CONTINUE READING

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