The phosphorothioic acid O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl ester exacerbates organophosphate polyneuropathy without inhibition of neuropathy target esterase.

@article{Moretto1994ThePA,
  title={The phosphorothioic acid O-(2-chloro-2,3,3-trifluorocyclobutyl) O-ethyl S-propyl ester exacerbates organophosphate polyneuropathy without inhibition of neuropathy target esterase.},
  author={Angelo Moretto and M. Bertolazzi and Marcello Lotti},
  journal={Toxicology and applied pharmacology},
  year={1994},
  volume={129 1},
  pages={
          133-7
        }
}
Organophosphate-induced delayed polyneuropathy (OPIDP) is thought to be initiated by a variety of neuropathy target esterase (NTE) inhibitors. However, certain inhibitors such as phenylmethanesulfonyl fluoride, phenyl N-methyl N-benzyl carbamate, and phenyl di-n-pentyl phosphinate protect from OPIDP when given to hens before organophosphorus esters. They protect from neuropathy by preventing the binding of neuropathic inhibitors to NTE catalytic site. In contrast, when such NTE inhibitors are… 
Repeated low doses of O-(2-chloro-2,3,3 trifluorocyclobutyl) O-ethyl S-propyl phosphorothioate (KBR-2822) do not cause neuropathy in hens
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Lack of neuropathy after repeated treatment with KBR-2822 indicates that a continuous promoting `pressure' on hen axons is harmless in the absence of a concurrent biochemical or neurotoxic injury.
Effects of S-ethyl hexahydro-1H-azepine-1-carbothioate (molinate) on di-n-butyl dichlorovinyl phosphate (DBDCVP) neuropathy.
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Protection from DBDCVP neuropathy by molinate is correlated with inhibition of NTE whereas promotion of DBDC VP neuropathy is associated with > 50% M200 inhibition.
Kinetic interactions of a neuropathy potentiator (phenylmethylsulfonyl fluoride) with the neuropathy target esterase and other membrane bound esterases
TLDR
This kinetic characterization study is needed for further isolation and molecular characterization studies, and these PMSF phenyl valerate esterase components will have to be considered in further studies of OPIDN promotion.
Toxicology elsewhere
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A novel stable precursor, saligenin phosphorotrichloridate, is synthesised, which on reaction with N-monobiotinyldiamines, generates a series of biotinylated covalent inhibitors of serine esterases, useful for detection and isolation of other serine Esterases.
Organophosphate polyneuropathy and neuropathy target esterase: Studies with methamidophos and its resolved optical isomers
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It is concluded that when racemic methamidophos is given to hens, initiation and protection from OPIDP is due to the interaction of d-(+) methamodophos with NTE, and both isomers are likely to be due to interactions with another unknown target.
Phenylmethylsulfonyl fluoride, a potentiator of neuropathy, alters the interaction of organophosphorus compounds with soluble brain esterases.
TLDR
Kinetic data of esterase inhibition were obtained for PMSF with a soluble chicken brain fraction and analyzed using a kinetic model with a multienzymatic system in which inhibition occurred with the simultaneous chemical hydrolysis of the inhibitor and ongoing inhibition (inhibition during the substrate reaction).
Triphenylphosphite neuropathy in hens
TLDR
TPP neuropathy in the hen is likely to be the same as typical OPIDP, and the unusual effects of combined treatment to hens with TPP and PMSF are explained by the prolonged pharmacokinetics of TPP and by the dual effect of PMSF i.e. protection from and promotion of OPIDs.
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