The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.

@article{Laffitte2003ThePT,
  title={The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions.},
  author={Bryan A. Laffitte and Sean B. Joseph and Mingyi Chen and Antonio Castrillo and Joyce J. Repa and Damien C Wilpitz and David J Mangelsdorf and Peter Tontonoz},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 6},
  pages={2182-91}
}
The liver X receptors (LXRs) are members of the nuclear receptor superfamily that are activated by oxysterols. In response to ligand binding, LXRs regulate a variety of genes involved in the catabolism, transport, and uptake of cholesterol and its metabolites. Here we demonstrate that LXRs also regulate plasma lipoprotein metabolism through control of the phospholipid transfer protein (PLTP) gene. LXR ligands induce the expression of PLTP in cultured HepG2 cells and mouse liver in vivo in a… CONTINUE READING