The phospholipase D1 pathway modulates macroautophagy.

@article{DallArmi2010ThePD,
  title={The phospholipase D1 pathway modulates macroautophagy.},
  author={Claudia Dall'Armi and Andr{\'e}s Hurtado-Lorenzo and Huasong Tian and Etienne Morel and Akiko Nezu and Robin Barry Chan and Wai Haung Yu and Kimberly S Robinson and Oladapo Yeku and Scott A. Small and Karen E Duff and Michael A. Frohman and Markus R. Wenk and Akitsugu Yamamoto and Gilbert Di Paolo},
  journal={Nature communications},
  year={2010},
  volume={1},
  pages={
          142
        }
}
Although macroautophagy is known to be an essential degradative process whereby autophagosomes mediate the engulfment and delivery of cytoplasmic components into lysosomes, the lipid changes underlying autophagosomal membrane dynamics are undetermined. Here, we show that phospholipase D1 (PLD1), which is primarily associated with the endosomal system, partially relocalizes to the outer membrane of autophagosome-like structures upon nutrient starvation. The localization of PLD1, as well as the… CONTINUE READING

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