The phospholipase C activating P2U purinoceptor also inhibits cyclicAMP formation in DDT1 MF-2 smooth muscle cells.

@article{Sipma1994ThePC,
  title={The phospholipase C activating P2U purinoceptor also inhibits cyclicAMP formation in DDT1 MF-2 smooth muscle cells.},
  author={Henny B. Sipma and A den Hertog and Adriaan Nelemans},
  journal={European journal of pharmacology},
  year={1994},
  volume={268 3},
  pages={
          431-7
        }
}
  • Henny B. Sipma, A den Hertog, Adriaan Nelemans
  • Published in
    European journal of…
    1994
  • Chemistry, Medicine
  • The P2U purinoceptor mediated effect on cellular cAMP was investigated in DDT1 MF-2 smooth muscle cells. Stimulation of these receptors by ATP or UTP caused a pronounced decrease of about 50% in cellular cAMP levels in forskolin or isoprenaline pretreated cells. This action of the nucleotides was concentration dependent with an IC50 of 9.4 +/- 0.2 microM and 29.0 +/- 0.5 microM for UTP and ATP, respectively and was inhibited by the P2-purinoceptor antagonist suramin. The cAMP level appeared to… CONTINUE READING

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