The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles.


A particular subgroup of toxins with phospholipase A(2) (PLA(2)) structure, but devoid of this enzymatic activity, is commonly found in the venoms of snakes of the family Viperidae, and known as the PLA(2) homologues. Among these, the most frequent type presents a lysine residue at position 49 (Lys49), in substitution of the otherwise conserved aspartate… (More)


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