The phosphoinositide hydrolase phospholipase C delta1 inhibits epithelial‐mesenchymal transition and is silenced in colorectal cancer

@article{Xiang2019ThePH,
  title={The phosphoinositide hydrolase phospholipase C delta1 inhibits epithelial‐mesenchymal transition and is silenced in colorectal cancer},
  author={Qin Xiang and Xiaoqian He and Junhao Mu and Haixi Mu and Dishu Zhou and Jun Tang and Qian Xiao and Yu Jiang and Guosheng Ren and Tingxiu Xiang and Weiyan Peng},
  journal={Journal of Cellular Physiology},
  year={2019},
  volume={234},
  pages={13906 - 13916}
}
In this study, we found that the phospholipase C delta1 (PLCD1) protein expression is reduced in colorectal tumor tissues compared with paired surgical margin tissues. PLCD1‐promoted CpG methylation was detected in 29/64 (45%) primary colorectal tumors, but not in nontumor tissues. The PLCD1 RNA expression was also reduced in three out of six cell lines, due to PLCD1 methylation. The ectopic expression of PLCD1 resulted in inhibited proliferation and attenuated migration of colorectal tumor… Expand
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Journal of Integrative Bioinformatics
  • 2020

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