The phosphoinositide hydrolase phospholipase C delta1 inhibits epithelial‐mesenchymal transition and is silenced in colorectal cancer

  title={The phosphoinositide hydrolase phospholipase C delta1 inhibits epithelial‐mesenchymal transition and is silenced in colorectal cancer},
  author={Qin Xiang and Xiaoqian He and Junhao Mu and Haixi Mu and Dishu Zhou and Jun Tang and Qian Xiao and Yu Jiang and Guosheng Ren and Tingxiu Xiang and Weiyan Peng},
  journal={Journal of Cellular Physiology},
  pages={13906 - 13916}
In this study, we found that the phospholipase C delta1 (PLCD1) protein expression is reduced in colorectal tumor tissues compared with paired surgical margin tissues. PLCD1‐promoted CpG methylation was detected in 29/64 (45%) primary colorectal tumors, but not in nontumor tissues. The PLCD1 RNA expression was also reduced in three out of six cell lines, due to PLCD1 methylation. The ectopic expression of PLCD1 resulted in inhibited proliferation and attenuated migration of colorectal tumor… Expand
The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling
ZNF471 functions as a tumor suppressor that was epigenetically inactivated in breast cancer and its inhibition of AKT and Wnt/β-catenin signaling pathways is one of the mechanisms underlying its anti-cancer effects. Expand
Phospholipase C Beta 2 Protein Overexpression Is a Favorable Prognostic Indicator in Newly Diagnosed Normal Karyotype Acute Myeloid Leukemia
It is suggested that PLC-β2 expression assessment using IHC allows prognosis prediction in NK-AML and only FLT3-ITD positivity was associated with a significantly low OS and high HR among the known prognostic markers. Expand
Noteworthy prognostic value of phospholipase C delta genes in early stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy and potential molecular mechanisms
PLCD3 may be a potential prognostic biomarker for early stage PDAC and is associated with angiogenesis, intracellular signal transduction, and regulation of cell proliferation. Expand
Journal of Integrative Bioinformatics
  • 2020


Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells
The expression of PLCδ1, one of the most basal PLCs, is down-regulated in CRC specimens compared with normal colon epithelium by immunohistochemistry, suggesting that PLC δ1 has tumor-suppressive functions in CRC through E-cadherin induction and KRAS/MEK/ERK signal attenuation. Expand
PLCD1 is a functional tumor suppressor inducing G2/M arrest and frequently methylated in breast cancer
This study for the first time demonstrates the frequent inactivation of PLCD1 by promoter methylation and its tumor inhibitory function in breast cancer. Expand
Epigenetic inactivation of PLCD1 in chronic myeloid leukemia.
Functional studies showed that ectopic expression of PLCD1 in K562 cells was able to dramatically inhibit their colony formation and induce cell cycle G1 arrest, suggesting that PLCd1 acts as a functional tumor suppressor and may serve as a biomarker for possible early detection and prognosis of CML. Expand
Phospholipase C delta 1 is a novel 3p22.3 tumor suppressor involved in cytoskeleton organization, with its epigenetic silencing correlated with high-stage gastric cancer
Ectopic expression of PLCD1 in silenced gastric tumor cells dramatically inhibited their clonogenicity and migration, possibly through downregulating MMP7 expression and hampering the reorganization of cytoskeleton through cofilin inactivation by phosphorylation. Expand
OPCML is frequently methylated in human colorectal cancer and its restored expression reverses EMT via downregulation of smad signaling.
OPCML is revealed as a potential tumor suppressor gene epigenetically silenced in colon cancer and will help to elucidate the anti-invasive mechanisms of OPCML and establish new chemotherapeutic strategies for human colon cancer. Expand
The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer
UCHL1 exerts its tumor suppressive functions by inducing G0/G1 cell cycle arrest and apoptosis in breast tumorigenesis, requiring its deubiquitinase activity. Expand
Phospholipase Cdelta1 is required for skin stem cell lineage commitment.
It is concluded that PLCdelta(1) is required for skin stem cell lineage commitment by observing many cysts that had remarkable similarities to interfollicular epidermis and sebaceous glands. Expand
Phospholipase Cδ1 is required for skin stem cell lineage commitment
It is concluded that PLCδ1 is required for skin stem cell lineage commitment by observing many cysts that had remarkable similarities to interfollicular epidermis as well as hyperplasia of sebaceous glands. Expand
TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells
It is concluded that TET1 exerts its anti-tumor functions in NPC cells by suppressing Wnt/β-catenin signaling via demethylation of Wnt antagonists (DACT2 and SFRP2). Expand
Autoregulation of E-cadherin expression by cadherin–cadherin interactions
This autoregulation of E-cadherin by cell–cell adhesion involving Slug, β-catenin and ERK could be important in tumorigenesis. Expand