The phosphoinositide 3-kinase signalling pathway as a therapeutic target in squamous cell carcinoma of the head and neck.

@article{Rogers2005TheP3,
  title={The phosphoinositide 3-kinase signalling pathway as a therapeutic target in squamous cell carcinoma of the head and neck.},
  author={Susanne J. Rogers and Carol Box and Kevin J. Harrington and Christopher M. Nutting and Peter Rhŷs-Evans and Suzanne A. Eccles},
  journal={Expert opinion on therapeutic targets},
  year={2005},
  volume={9 4},
  pages={769-90}
}
Squamous cell carcinoma of the head and neck (SCCHN) is associated with high morbidity and mortality. Despite significant surgical advances and refinement in the delivery of chemotherapy and radiotherapy, prognosis has improved little in recent decades. Better local control has led to the late presentation of distant metastases and novel therapeutic agents are urgently required to prevent relapse, control disseminated disease and thus improve survival. PIK3CA encodes the p110alpha isoform of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…