The phosphoinositide 3-kinase pathway.

@article{Cantley2002TheP3,
  title={The phosphoinositide 3-kinase pathway.},
  author={Lewis C. Cantley},
  journal={Science},
  year={2002},
  volume={296 5573},
  pages={
          1655-7
        }
}
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and… CONTINUE READING
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