The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice.

@article{Liang1998ThePI,
  title={The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice.},
  author={Li-fang Liang and Evette Beshay and Gerald Joseph Prud'homme},
  journal={Diabetes},
  year={1998},
  volume={47 4},
  pages={570-5}
}
Interleukin (IL)-12, interferon (IFN)-gamma, and other inflammatory cytokines play an important role in the pathogenesis of autoimmune insulitis and diabetes in NOD mice, and inhibition of these cytokines is likely to be beneficial. In this study, we found that Pentoxifylline (PTX) and Rolipram (phosphodiesterase [PDE] inhibitors that induce increased intracellular cAMP) can block inflammatory cytokine production. Inhibition of IL-12 and IFN-gamma secretion was demonstrated in macrophages… CONTINUE READING
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