The phosphodiesterase 5 inhibitor tadalafil regulates lipidic homeostasis in human skeletal muscle cell metabolism

@article{Marampon2017TheP5,
  title={The phosphodiesterase 5 inhibitor tadalafil regulates lipidic homeostasis in human skeletal muscle cell metabolism},
  author={Francesco Marampon and Cristina Antinozzi and Clarissa Corinaldesi and Gabriella Barbara Vannelli and Erica Sarchielli and Silvia Migliaccio and Luigi Di Luigi and Andrea Lenzi and Clara Crescioli},
  journal={Endocrine},
  year={2017},
  volume={59},
  pages={602-613}
}
Tadalafil seems to ameliorate insulin resistance and glucose homeostasis in humans. We have previously reported that tadalafil targets human skeletal muscle cells with an insulin (I)-like effect. We aim to evaluate in human fetal skeletal muscle cells after tadalafil or I: (i) expression profile of I-regulated genes dedicated to cellular energy control, glycolitic activity or microtubule formation/vesicle transport, as GLUT4, PPARγ, HK2, IRS-1, KIF1C, and KIFAP3; (ii) GLUT4, Flotillin-1, and… CONTINUE READING