The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats.

@article{Wang2012ThePI,
  title={The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats.},
  author={Chuang Wang and Xue-mei Yang and Ye-Ye Zhuo and Heng Zhou and Huan-bing Lin and Yu-Fang Cheng and Jiangping Xu and Han Zhang},
  journal={The international journal of neuropsychopharmacology},
  year={2012},
  volume={15 6},
  pages={749-66}
}
β-amyloid (Aβ) peptides play an important role in cognition deficits, neuroinflammation, and apoptosis observed in Alzheimer's disease (AD). Activation of cyclic AMP (cAMP) signalling enhances memory and inhibits inflammatory and apoptotic responses. However, it is not known whether inhibition of phosphodiesterase-4 (PDE4), a critical controller of intracellular cAMP concentrations, affects AD-associated neuroinflammatory and apoptotic responses and whether these responses contribute to… CONTINUE READING