The phosphatonin pathway: new insights in phosphate homeostasis.

  title={The phosphatonin pathway: new insights in phosphate homeostasis.},
  author={Susan C. Schiavi and Rajiv Kumar},
  journal={Kidney international},
  volume={65 1},
Serum phosphate concentrations are maintained within a defined range by processes that regulate the intestinal absorption and renal excretion of inorganic phosphate. The hormones currently believed to influence these processes are parathyroid hormone (PTH) and the active metabolite of vitamin D, 1alpha,25-dihydroxyvitamin D (1alpha,25(OH)2D). A new class of phosphate-regulating factors, collectively known as the phosphatonins, have been shown to be associated with the hypophosphatemic diseases… CONTINUE READING


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