The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal

@article{Bse2004ThePR,
  title={The phosphatidylserine receptor has essential functions during embryogenesis but not in apoptotic cell removal},
  author={Jens B{\"o}se and Achim D. Gruber and Laura Helming and Stefanie Schiebe and Ivonne Wegener and Martin Hafner and M P Beales and Frank Koentgen and Andreas Lengeling},
  journal={Journal of Biology},
  year={2004},
  volume={3},
  pages={15 - 15}
}
Background Phagocytosis of apoptotic cells is fundamental to animal development, immune function and cellular homeostasis. The phosphatidylserine receptor (Ptdsr) on phagocytes has been implicated in the recognition and engulfment of apoptotic cells and in anti-inflammatory signaling. To determine the biological function of the phosphatidylserine receptor in vivo, we inactivated the Ptdsr gene in the mouse. Results Ablation of Ptdsr function in mice causes perinatal lethality, growth… Expand
The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis
TLDR
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Identification of Tim4 as a phosphatidylserine receptor
TLDR
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Phospholipids: Key Players in Apoptosis and Immune Regulation
TLDR
The role of PS exposure in the clearance process of dead cells and its implications in clinical situations where apoptosis plays a relevant role, like in cancer, chronic autoimmunity, and infections are focused on. Expand
Oxidized phosphatidylserine–CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells
TLDR
It is shown that the class B scavenger receptor CD36 plays an essential role in macrophage clearance of apoptotic cells in vivo and mass spectrometry analyses of oxPS species identify structures of candidate ligands for CD36 in apoptotic membranes that may facilitate macrophages' recognition. Expand
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TLDR
Understanding the role of PS in membranes of dying cells and microvesicles will help to develop novel drugs and treatment options for controlling immune-mediated diseases like chronic autoimmunity and cancer. Expand
Apoptotic cell removal in development and tissue homeostasis.
TLDR
This review will discuss cell deletion in relation to the development and function of the innate immune system, particularly of the mononuclear phagocyte system (MPS), its ontogeny and potential role in tissue remodeling in the embryo and adult. Expand
MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure.
TLDR
The importance of the MFG-E8-mediated clearance of apoptotic cells in the prevention of autoimmune diseases is discussed. Expand
Aminophospholipid Translocase TAT-1 Promotes Phosphatidylserine Exposure during C. elegans Apoptosis
TLDR
It is shown that PS exposure can readily be detected on apoptotic C. elegans cells, and it is proposed that tat-1 homologs might also play an important role in PS exposure in mammals. Expand
Engulfment of Apoptotic Cells and Its Physiological Roles
TLDR
Apoptotic cells are swiftly removed by phagocytes in a Rac1-dependent manner and engulfed efficiently, which leads to local inflammation, production of autoantibodies, and SLE (systemic lupus erythematosus)-type autoimmune diseases. Expand
The role of phosphatidylserine recognition receptors in multiple biological functions
Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis. Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase-dependent apoptosis,Expand
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References

SHOWING 1-10 OF 64 REFERENCES
Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells
TLDR
A critical role for PSR in early stages of mammalian organogenesis is demonstrated and it is suggested that this receptor may be involved in respiratory distress syndromes and congenital brain malformations. Expand
Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor.
TLDR
During embryonic development, PSR-mediated apoptotic cell uptake is required for definitive erythropoiesis and T lymphopoies is, independently of the prevention of inflammatory responses. Expand
Transglutaminase 2-/- mice reveal a phagocytosis-associated crosstalk between macrophages and apoptotic cells
  • Z. Szondy, Z. Sarang, +13 authors L. Fésüs
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
TLDR
It is reported that apoptosis could be induced in TGase2-/- mice; however, the clearance of apoptotic cells was defective during the involution of thymus elicited by dexamethasone, anti-CD3 antibody, or γ-irradiation, and in the liver after induced hyperplasia. Expand
A receptor for phosphatidylserine-specific clearance of apoptotic cells
TLDR
Using phage display, a gene that appears to recognize phosphatidylserine on apoptotic cells is cloned and shown to be highly homologous to genes of unknown function in Caenorhabditis elegans and Drosophila melanogaster, suggesting that phosphatido-serine recognition on apoptosis cells during their removal by phagocytes is highly conserved throughout phylogeny. Expand
The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity
TLDR
The results suggest that Hydra PSR is a nuclear 2-oxoglutarate (2OG)-and Fe(II)-dependent oxygenase, in contrast with the proposed function of Hydra PSS as a cell surface receptor involved in the recognition of apoptotic cells displaying phosphatidylserine on their surface. Expand
Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.
TLDR
The data suggest that macrophages specifically recognize phosphatidylserine that is exposed on the surface of lymphocytes during the development of apoptosis, and suggest that apoptotic lymphocytes lose membrane phospholipid asymmetry and expose phosphorus on the outer leaflet of the plasma membrane. Expand
Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice
TLDR
It is reported that tingible body macrophages in the germinal centers of the spleen and lymph nodes strongly express MFG-E8, a protein that binds to apoptotic cells by recognizing phosphatidylserine and that enhances the engulfment of apoptosis cells by macrophage. Expand
Phagocytosis and clearance of apoptotic cells is mediated by MER
TLDR
The Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells, which has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus. Expand
Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina
TLDR
It is shown that cell death during normal retinal development is important for the modeling of a functional vision organ and showed that the pro‐apoptotic BAX protein plays a crucial role in this process. Expand
Human CD14 mediates recognition and phagocytosis of apoptotic cells
TLDR
Results indicate that clearance of apoptotic cells is mediated by a receptor whose interactions with ‘non-self’ components (LPS) and ‘self” components (apoptotic cells) produce distinct macrophage responses. Expand
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