The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation.

@article{Tabuchi2006TheP4,
  title={The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation.},
  author={Mitsuaki Tabuchi and Anjon Audhya and Ainslie B. Parsons and Charles Boone and Scott D Emr},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 15},
  pages={5861-75}
}
The Stt4 phosphatidylinositol 4-kinase has been shown to generate a pool of phosphatidylinositol 4-phosphate (PI4P) at the plasma membrane, critical for actin cytoskeleton organization and cell viability. To further understand the essential role of Stt4-mediated PI4P production, we performed a genetic screen using the stt4(ts) mutation to identify candidate regulators and effectors of PI4P. From this analysis, we identified several genes that have been previously implicated in lipid metabolism… CONTINUE READING

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