The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10.

@article{Dahle2004TheP3,
  title={The phosphatidylinositol 3-kinase/protein kinase B signaling pathway is activated by lipoteichoic acid and plays a role in Kupffer cell production of interleukin-6 (IL-6) and IL-10.},
  author={Maria Krudtaa Dahle and Gunhild \Overland and Anders E Myhre and Jon Fredrik Stuest\ol and Thomas Hartung and Claus Danckert Krohn and \Oystein Mathiesen and Jacob E Wang and Ansgar Oddne Aasen},
  journal={Infection and immunity},
  year={2004},
  volume={72 10},
  pages={5704-11}
}
Sepsis caused by gram-positive bacteria lacking lipopolysaccharide (LPS) has become a major and increasing cause of mortality in intensive-care units. We have recently demonstrated that the gram-positive-specific bacterial cell wall component lipoteichoic acid (LTA) stimulates the release of the proinflammatory cytokines in Kupffer cells in culture. In the present study, we have started to assess the signal transduction events by which LTA induces the production of tumor necrosis factor alpha… CONTINUE READING

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