The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.

@article{Vivanco2010ThePA,
  title={The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.},
  author={Igor Vivanco and Daniel Rohle and Matthias Versele and Akio Iwanami and Daisuke Kuga and Barbara Oldrini and Kazuhiro Tanaka and Julie Dang and Sara P. Kubek and Nicolaos Palaskas and Teli Hsueh and Michael Evans and David J. Mulholland and Daniel G Wolle and Sigrid A. Rajasekaran and Ayyappan Rajasekaran and L M Liau and Timothy F. Cloughesy and Ivan Dikic and C. V. Weiss Brennan and Hong Wu and Paul Mischel and Timothy P S Perera and Ingo K. Mellinghoff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 14},
  pages={6459-64}
}
The phosphatase and tensin homolog (PTEN) is a tumor suppressor that is inactivated in many human cancers. PTEN loss has been associated with resistance to inhibitors of the epidermal growth factor receptor (EGFR), but the molecular basis of this resistance is unclear. It is believed that unopposed phosphatidylinositol-3-kinase (PI3K) activation through multiple receptor tyrosine kinases (RTKs) can relieve PTEN-deficient cancers from their "dependence" on EGFR or any other single RTK for… CONTINUE READING