The phosphatase PTPL1 is required for PTEN-mediated regulation of apical membrane size.

Abstract

PTEN is a tumor suppressor frequently lost in epithelial malignancies. Part of the tumor suppressive properties of PTEN is attributed to its function in cell polarization and consequently its role in maintaining epithelial tissue integrity. However, surprisingly little is known about the function and regulation of PTEN during epithelial cell polarization.We… (More)
DOI: 10.1128/MCB.00102-18

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