The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2.

@article{Davidson2010ThePP,
  title={The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2.},
  author={Dominique Davidson and Xiaochu Shi and Ming-Chao Zhong and Inmoo Rhee and Andr{\'e} Veillette},
  journal={Immunity},
  year={2010},
  volume={33 2},
  pages={167-80}
}
PTP-PEST (encoded by Ptpn12) is an intracellular protein tyrosine phosphatase belonging to the same family as LYP. LYP inhibits secondary T cell responses by suppressing Src family protein tyrosine kinases and is implicated in human autoimmunity. To determine the function of PTP-PEST in T cells, we generated mice with a conditionally deleted allele of Ptpn12. By removing PTP-PEST in T cells, we determined that PTP-PEST was not necessary for T cell development or primary responses. However, PTP… CONTINUE READING

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2006).Role ofPTPN22 in type1 diabetes and other autoimmune diseases

  • N. Bottini, T. Vang, F. Cucca, T. andMustelin
  • Semin. Immunol
  • 2006
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