The phenotypic variability of amyotrophic lateral sclerosis

@article{Swinnen2014ThePV,
  title={The phenotypic variability of amyotrophic lateral sclerosis},
  author={Bart Swinnen and Wim Robberecht},
  journal={Nature Reviews Neurology},
  year={2014},
  volume={10},
  pages={661-670}
}
Classic textbook neurology teaches that amyotrophic lateral sclerosis (ALS) is a degenerative disease that selectively affects upper and lower motor neurons and is fatal 3–5 years after onset—a description which suggests that the clinical presentation of ALS is very homogenous. However, clinical and postmortem observations, as well as genetic studies, demonstrate that there is considerable variability in the phenotypic expression of ALS. Here, we review the phenotypic variability of ALS and how… 

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