The phenotypic variability of amyotrophic lateral sclerosis

@article{Swinnen2014ThePV,
  title={The phenotypic variability of amyotrophic lateral sclerosis},
  author={B. Swinnen and W. Robberecht},
  journal={Nature Reviews Neurology},
  year={2014},
  volume={10},
  pages={661-670}
}
  • B. Swinnen, W. Robberecht
  • Published 2014
  • Medicine
  • Nature Reviews Neurology
  • Classic textbook neurology teaches that amyotrophic lateral sclerosis (ALS) is a degenerative disease that selectively affects upper and lower motor neurons and is fatal 3–5 years after onset—a description which suggests that the clinical presentation of ALS is very homogenous. However, clinical and postmortem observations, as well as genetic studies, demonstrate that there is considerable variability in the phenotypic expression of ALS. Here, we review the phenotypic variability of ALS and how… CONTINUE READING
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    References

    SHOWING 1-10 OF 137 REFERENCES
    Clinical and genetic heterogeneity of amyotrophic lateral sclerosis
    • 83
    The Frontotemporal Syndromes of ALS. Clinicopathological Correlates
    • 39
    Autonomic impairment in amyotrophic lateral sclerosis
    • 94
    State of play in amyotrophic lateral sclerosis genetics
    • 980
    • Highly Influential
    • PDF
    ALS motor phenotype heterogeneity, focality, and spread
    • 426
    The epidemiology of ALS: a conspiracy of genes, environment and time
    • 438
    • PDF
    The changing scene of amyotrophic lateral sclerosis
    • 728
    • PDF
    Cognitive impairment in amyotrophic lateral sclerosis
    • 267