The phenotypic evolution of Pseudomonas aeruginosa populations changes in the presence of subinhibitory concentrations of ciprofloxacin.

@article{Wassermann2016ThePE,
  title={The phenotypic evolution of Pseudomonas aeruginosa populations changes in the presence of subinhibitory concentrations of ciprofloxacin.},
  author={Tina Wassermann and Karin Meinike J{\o}rgensen and Karolina Ivanyshyn and Thomas Bjarnsholt and S. M. Hossein Khademi and Lars Jelsbak and Niels H{\o}iby and Oana Ciofu},
  journal={Microbiology},
  year={2016},
  volume={162 5},
  pages={
          865-75
        }
}
Ciprofloxacin is a widely used antibiotic, in the class of quinolones, for treatment of Pseudomonas aeruginosa infections. The immediate response of P. aeruginosa to subinhibitory concentrations of ciprofloxacin has been investigated previously. However, the long-term phenotypic adaptation, which identifies the fitted phenotypes that have been selected during evolution with subinhibitory concentrations of ciprofloxacin, has not been studied. We chose an experimental evolution approach to… CONTINUE READING
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