The phenomenon of treatment failures in Human African Trypanosomiasis

@article{Brun2001ThePO,
  title={The phenomenon of treatment failures in Human African Trypanosomiasis},
  author={Reto Brun and Reto Schumacher and C{\'e}cile Schmid and Christina Kunz and Christian Burri},
  journal={Tropical Medicine \& International Health},
  year={2001},
  volume={6}
}
Treatment of Human African Trypanosomiasis (HAT or sleeping sickness) relies on a few drugs which are old, toxic and expensive. The most important drug for the treatment of second stage infection is melarsoprol. During the last 50 years treatment failures with melarsoprol were not a major problem in Trypanosoma brucei gambiense patients. Commonly a relapse rate of 5–8% was reported, but in recent years it has increased dramatically in some important foci of T. b. gambiense sleeping sickness… 
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