The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence.

@article{Sinsimer2008ThePG,
  title={The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence.},
  author={Daniel Sinsimer and Gaelle Huet and Claudia Manca and Liana Georgieva Tsenova and Mi-Sun Koo and Natalia Kurepina and Bavesh Davandra Kana and Barun Mathema and Salvatore A. E. Marras and Barry Kreiswirth and Christophe Guilhot and Gilla Kaplan},
  journal={Infection and immunity},
  year={2008},
  volume={76 7},
  pages={3027-36}
}
Mycobacterium tuberculosis possesses a diversity of potential virulence factors including complex branched lipids such as the phenolic glycolipid PGL-tb. PGL-tb expression by the clinical M. tuberculosis isolate HN878 has been associated with a less efficient Th1 response and increased virulence in mice and rabbits. It has been suggested that the W-Beijing family is the only group of M. tuberculosis strains with an intact pks1-15 gene, required for the synthesis of PGL-tb and capable of… CONTINUE READING

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