The phenobarbital-induced transcriptional activation of cytochrome P-450 genes is blocked by the glucocorticoid-progesterone antagonist RU486.

Abstract

Several of the hepatic microsomal cytochromes P450 can be induced by various drugs and xenobiotics, among them the barbiturate phenobarbital. Rat hepatoma cells (Fao and its derivatives) respond to phenobarbital or dexamethasone treatment with an increased accumulation of CYP2C6 mRNA and thus provide a culture system to investigate the mechanisms involved… (More)

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@article{Shaw1993ThePT, title={The phenobarbital-induced transcriptional activation of cytochrome P-450 genes is blocked by the glucocorticoid-progesterone antagonist RU486.}, author={Pamela M Shaw and Milton Adesnik and Mary C. Weiss and Laurent Corcos}, journal={Molecular pharmacology}, year={1993}, volume={44 4}, pages={775-83} }