The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes

@article{Srikhanta2010ThePP,
  title={The phasevarion: phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes},
  author={Yogitha N. Srikhanta and Kate L. Fox and Michael P Jennings},
  journal={Nature Reviews Microbiology},
  year={2010},
  volume={8},
  pages={196-206}
}
In several host-adapted pathogens, phase variation has been found to occur in genes that encode methyltransferases associated with type III restriction–modification systems. It was recently shown that in the human pathogens Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis phase variation of a type III DNA methyltransferase, encoded by members of the mod gene family, regulates the expression of multiple genes. This novel genetic system has been termed the 'phasevarion… CONTINUE READING

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