The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.


Predictive pharmacophore models were developed for a large series of I(Kr) potassium channel blockers as class III antiarrhythmic agents using HypoGen in Catalyst software. The pharmacophore hypotheses were generated using a training set consisting of 34 compounds carefully selected from documents. Their biological data, expressed as IC(50), spanned from 1… (More)


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