The pharmacology of the internal anal sphincter and new treatments of ano-rectal disorders.

Abstract

Surgical options for faecal incontinence in the presence of intact sphincters are limited. Furthermore, in patients with fissures, lateral sphincterotomy reduces anal sphincter hypertonia but there has been concern about complications. A greater understanding of the basic pharmacology of the internal anal sphincter has led to the development of novel… (More)

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Cite this paper

@article{Cook2001ThePO, title={The pharmacology of the internal anal sphincter and new treatments of ano-rectal disorders.}, author={Tim A Cook and Alison Frances Brading and N. J. M. C. Mortensen}, journal={Alimentary pharmacology & therapeutics}, year={2001}, volume={15 7}, pages={887-98} }