The pharmacology of psilocybin

@article{Passie2002ThePO,
  title={The pharmacology of psilocybin},
  author={Torsten Passie and Juergen Dr Seifert and Udo Schneider and Hinderk M. Emrich},
  journal={Addiction Biology},
  year={2002},
  volume={7}
}
Psilocybin (4‐phosphoryloxy‐N,N‐dimethyltryptamine) is the major psychoactive alkaloid of some species of mushrooms distributed worldwide.These mushrooms represent a growing problem regarding hallucinogenic drug abuse. Despite its experimental medical use in the 1960s, only very few pharmacological data about psilocybin were known until recently. Because of its still growing capacity for abuse and the widely dispersed data this review presents all the available pharmacological data about… 
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The focus is laid on l-tryptophan and the various Psilocybe natural products and their metabolic routes are highlighted, and pharmacological, medicinal, ecological, biochemical, and evolutionary aspects are included.
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An in-depth review of the study design and results of psilocybin use in each of the mental health disease states and symptoms and discusses the clinical potential for use is provided.
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The classical hallucinogens having an affinity towards 5HT2A receptors are discussed, along with their common behavioral effects, toxicity and psychiatric complications which could have long-term…
Chapter 5 - Bioactive Alkaloids of Hallucinogenic Mushrooms
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